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Update: Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

The combination of nirmatrelvir with ritonavir (Paxlovid®) is a new medicine developed to treat infection with the SARS‐CoV‐2 virus and aims to avoid severe COVID‐19 in people without symptoms, or those with mild symptoms. This review update assesses the efficacy and safety of nirmatrelvir/ritonavir plus standard of care (SoC) compared to SoC with or without placebo, or any other intervention for treating COVID-19 or preventing SARS-CoV-2 infection.

Cochrane Systematic Review: UPDATE

Updated: WHO Guidelines for malaria

The latest version of the WHO Guidelines for malaria was updated in October 2023. These Guidelines supersede 2 previous WHO publications: the Guidelines for the treatment of malaria, third edition and the Guidelines for malaria vector control.

Dissemination products

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Update: Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

The combination of nirmatrelvir with ritonavir (Paxlovid®) is a new medicine developed to treat infection with the SARS‐CoV‐2 virus and aims to avoid severe COVID‐19 in people without symptoms, or those with mild symptoms. This review update assesses the efficacy and safety of nirmatrelvir/ritonavir plus standard of care (SoC) compared to SoC with or without placebo, or any other intervention for treating COVID-19 or preventing SARS-CoV-2 infection.

Cochrane Systematic Review: UPDATE

Updated: WHO Guidelines for malaria

The latest version of the WHO Guidelines for malaria was updated in October 2023. These Guidelines supersede 2 previous WHO publications: the Guidelines for the treatment of malaria, third edition and the Guidelines for malaria vector control.

Dissemination products

The impact of growth monitoring and promotion on health indicators in children under five years of age in low‐ and middle‐income countries

There is limited and uncertain evidence on the effectiveness of growth monitoring and promotion on key child health indicators state the authors of this Cochrane review Note: this Cochrane Review supersedes the published Cochrane Review Panpanich 1999.

Cochrane Systematic Review: NEW

Cluster-randomized controlled trials: a tutorial

This tutorial focuses on cluster-randomized controlled trials (cluster-RCTs). What cluster-RCTs are, why they might be used, and how to include data from cluster-RCTs in systematic reviews.

Peer-reviewed article

Topical repellents for malaria prevention

This Cochrane Review aims to measure the effectiveness of topical repellents to prevent malaria infection among high‐ and non‐high‐risk populations living in malaria‐endemic regions.

Cochrane Systematic Review: NEW

Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post-COVID-19 condition

In this review the authors examine the theory that amyloid fibrin(ogen) particles (sometimes called “microclots”) are a feature of post-COVID-19 condition and investigate whether there is evidence that plasmapheresis may be an appropriate treatment to remove these particles

Cochrane Systematic Review: NEW

A health systems approach to critical care delivery in low-resource settings: a narrative review

In this narrative review the authors examine critical care capacity building in low-income countries from a health systems perspective

Peer-reviewed article

Use of hospital services by patients with chronic conditions in sub-Saharan Africa: a systematic review and meta-analysis

The objective of this publication was to estimate the prevalence of individual chronic conditions and multimorbidity among adults admitted to hospital in sub–Saharan Africa.

Peer-reviewed article

WHO guideline on policies to protect children from the harmful impact of food marketing

This WHO guideline provides Member States with recommendations and implementation considerations on policies to protect children from the harmful impact of food marketing, based on evidence specific to children and to the context of food marketing.

Dissemination products

Effects of policies or interventions that influence the school food environment on children’s health and nonhealth outcomes: a systematic review

This systematic review aimed to assess the effects of implementing policies or interventions that influence the school food environment on children’s health and nonhealth outcomes

Peer-reviewed article

Obesity as an independent risk factor for COVID‐19 severity and mortality

This review evaluates obesity as an independent prognostic factor for COVID‐19 severity and mortality among adult patients in whom infection with the COVID‐19 virus is confirmed.

Cochrane Systematic Review: NEW

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children

The authors of this review evaluated the benefits and harms of balanced solutions for the rapid rehydration of children with severe dehydration due to acute diarrhoea, in terms of time in hospital and mortality compared to 0.9% saline.

Cochrane Systematic Review: NEW

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