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Update: Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

The combination of nirmatrelvir with ritonavir (Paxlovid®) is a new medicine developed to treat infection with the SARS‐CoV‐2 virus and aims to avoid severe COVID‐19 in people without symptoms, or those with mild symptoms. This review update assesses the efficacy and safety of nirmatrelvir/ritonavir plus standard of care (SoC) compared to SoC with or without placebo, or any other intervention for treating COVID-19 or preventing SARS-CoV-2 infection.

Cochrane Systematic Review: UPDATE

Updated: WHO Guidelines for malaria

The latest version of the WHO Guidelines for malaria was updated in October 2023. These Guidelines supersede 2 previous WHO publications: the Guidelines for the treatment of malaria, third edition and the Guidelines for malaria vector control.

Dissemination products

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Should all pregnant women take calcium supplements in Nepal? GRADE evidence to policy assessment

This review aimed to assess whether the current evidence supports the blanket supplementation of calcium to prevent pre-eclampsia among pregnant women in Nepal

Peer-reviewed article

'Interpretation of subgroup analyses', Cochrane Methods Support Unit web clinic, 13 October 2022

Dr Marty Chaplin, CIDG Statistical Editor, presented on the interpretation of subgroup analyses in Cochrane reviews

Air and surface sampling for monkeypox virus in a UK hospital: an observational study

New study finds that monkeypox virus can spread widely within specialist hospital isolation rooms

Peer-reviewed article

Update: House modifications for preventing malaria

Research in 1900 suggested house modifications may reduce malaria transmission. A previous version of this review concluded that house screening may be effective in reducing malaria. This update includes data from five new studies.

Cochrane Systematic Review: UPDATE

WHO Consolidated guidelines on TB: Module 5: Management of tuberculosis in children and adolescents

These WHO guidelines were published in March 2022, and updated in September 2022.

Dissemination products

Podcast: How accurate are rapid antigen tests for diagnosing COVID-19?

Listen to this podcast on how accurate are rapid antigen tests for diagnosing COVID-19?

Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

The combination of nirmatrelvir with ritonavir (Paxlovid®) is a new medicine developed to treat infection with the SARS‐CoV‐2 virus and aims to avoid severe COVID‐19 in people without symptoms, or those with mild symptoms. This new review assessed the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid®) plus standard of care compared to standard of care with or without placebo, or any other intervention for treating COVID‐19 and for preventing SARS‐CoV‐2 infection

Cochrane Systematic Review: NEW

Truth not Triumph: backstage at CIDG. Valedictory lecture by Professor Paul Garner

Truth not Triumph: backstage at CIDG. Valedictory lecture by Professor Paul Garner

Storyboarding HIV infected young people’s adherence to antiretroviral therapy in lower- to upper middle-income countries: a new-materialist qualitative evidence synthesis

In this qualitative evidence synthesis review, the authors study the complex configuration of different agents that impact therapy adherence of young people living with perinatal infections of HIV.

Peer-reviewed article

Update: Adding rapid diagnostic tests to community‐based programmes for treating malaria

The WHO recommends parasitological testing of all suspected malaria cases using malaria rapid diagnostic tests (mRDTs) or microscopy prior to treatment. This update of a 2013 Cochrane Review examines whether adding mRDTs to community-based malaria programmes improves treatment of people with malaria or fever.

Cochrane Systematic Review: UPDATE

Update: 'Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children'

This review update (original version published 27 August 2020) examines the evidence from the previous review in assessing the diagnostic accuracy of Xpert Ultra for detecting: pulmonary tuberculosis, tuberculous meningitis, lymph node tuberculosis, and rifampicin resistance, in children with presumed tuberculosis.

Cochrane Systematic Review: UPDATE

Identifying and managing problematic trials: a Research Integrity Assessment (RIA) tool for randomized controlled trials in evidence synthesis

Ensuring research integrity of studies included in evidence synthesis is an approach that helps to provide evidence closer to the unbiased truth and improves respect of human rights in evidence synthesis. In this paper, the author team explains the rationale and application of a Research Integrity Assessment tool for randomized controlled trials for the update of a Cochrane Review.

Peer-reviewed article

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