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Cochrane reviews

Cochrane Reviews from READ-It Partners in the Cochrane Database of Systematic Reviews.

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Tafenoquine for preventing relapse in people with Plasmodium vivax malaria

The aim of this review was to see if tafenoquine could prevent relapses of vivax infections and if this effect is equivalent to that of standard‐dose primaquine.

Cochrane Systematic Review: UPDATE

Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

The aim of this review is to determine the accuracy of tests in symptomatic children for diagnosing pulmonary tuberculosis, tuberculous meningitis, lymph node tuberculosis, and rifampicin resistance.

Cochrane Systematic Review: NEW

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Insecticide space spraying for preventing malaria transmission

In order to guide decision‐making for malaria control programmes, the aim of this Cochrane Review was to summarize the actions taken and reported findings of trials evaluating the impact of space spraying on malaria transmission.

Cochrane Systematic Review: NEW

Podcast: Xpert® MTB/RIF test for diagnosing extrapulmonary tuberculosis and rifampicin resistance

Most Cochrane Reviews look at the effects of interventions on health, but a growing number are providing g evidence on the accuracy of different ways of diagnosing a disease. The review’s first author, Mikashmi Kohli from McGill University in Montreal Canada, sets the scene and tells us what they found in this podcast.

Foodborne and Food-Handler Norovirus Outbreaks: A Systematic Review

Norovirus (NoV) is the commonest cause of gastrointestinal disease in the United Kingdom and in many developed countries, causing diarrhea and vomiting in millions of cases worldwide annually. Transmission is most often mediated from person to person.

Peer-reviewed article

Antibiotics for treating scrub typhus

The aim of this Cochrane Review is to find out whether certain antibiotics are more effective in treating scrub typhus. We collected and analysed all relevant studies to answer this question and included seven studies.

Cochrane Systematic Review: UPDATE

Primary antifungal prophylaxis for cryptococcal disease in HIV -positive people

The aim of this Cochrane Review was to find out if taking an antifungal drug regularly, such as fluconazole, prevented HIV‐positive people who have low cluster of differentiation 4 (CD4) cell counts, from getting cryptococcal disease, and what the potential complications were.

Cochrane Systematic Review: UPDATE

Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

To find out how accurate Xpert® MTB/RIF (Xpert) is for diagnosing extrapulmonary TB and drug resistance. We included eight forms of extrapulmonary TB: tuberculous meningitis and pleural, lymph node, bone or joint, genitourinary, peritoneal, pericardial, and disseminated TB.

Cochrane Systematic Review: NEW

Credit: Photo by Jacob Arthur-Quarm – Ghana

Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease)

The aim of this Cochrane Review was to summarize the evidence for drug treatments for Buruli ulcer.

Cochrane Systematic Review: NEW

Treatment for HIV‐associated cryptococcal meningitis

The aim of this Cochrane Review was to find the best therapy to reduce the risk of death from cryptococcal meningitis in HIV‐positive individuals.

Cochrane Systematic Review: UPDATE

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis

The aim of this Cochrane Review was to determine whether initiating antiretroviral therapy (ART) within four weeks of cryptococcal meningitis diagnosis resulted in a higher risk of dying or developing other complications than waiting more than four weeks to initiate ART.

Cochrane Systematic Review: UPDATE

Effects of total fat intake on bodyweight in children

What is the relationship between the amount of fat a child eats and their weight and body fat?

Cochrane Systematic Review: NEW

Revision of the ARRIVE guidelines: rationale and scope

In 2010, the NC3Rs published the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines to improve the reporting of animal research. Despite considerable levels of support from the scientific community, the impact on the quality of reporting in animal research publications has been limited. This position paper highlights the strategy of an expert working group established to revise the guidelines and facilitate their uptake.

Peer-reviewed article

Ribavirin for treating Crimean Congo haemorrhagic fever

Crimean Congo haemorrhagic fever (CCHF) is an infection transmitted to humans by tick bites.

Cochrane Systematic Review: NEW

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