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Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children

The authors of this review evaluated the benefits and harms of balanced solutions for the rapid rehydration of children with severe dehydration due to acute diarrhoea, in terms of time in hospital and mortality compared to 0.9% saline.

Cochrane Systematic Review: NEW

Patient adherence to tuberculosis treatment in the Indian subcontinent: systematic review and meta-synthesis of qualitative research

How well patients adhere to their tuberculosis (TB) treatment influences their recovery and development of drug resistance, but influences on adherence are multiple and often competing. The authors synthesised qualitative studies from a setting in the Indian subcontinent to understand the dimensions and dynamics involved to help inform service provision.

Peer-reviewed article

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Updated Podcast: Xpert Ultra compared to Xpert MTB/RIF for diagnosing pulmonary tuberculosis and rifampicin resistance in adults

Lead author, Jerry Zifodya from Tulane University in New Orleans, USA, talks about the latest finding in this podcast.

Updated Podcast: How accurate is chest imaging for diagnosing COVID-19?

Lead author of the March 2021 update, Nayaar Islam from The Ottawa Hospital Research Institute in Canada, describes the latest findings in this podcast.

Podcast: How accurate are rapid tests for diagnosing COVID-19?

Several COVID-19 reviews relate to diagnosis. One of these, on the use of rapid point-of-care tests was updated in March 2021. Lead author Jacqueline Dinnes from the University of Birmingham in the UK tells us what they found for antigen tests.

Update (24 Mar 2021): Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection

This is a review update of the original version (published 26 August 2020). The authors now include 64 study reports in 78 study cohorts, evaluating 16 antigen and 5 molecular assays.

Cochrane Systematic Review: UPDATE

Xpert MTB/RIF and Xpert Ultra assays for screening for pulmonary tuberculosis and rifampicin resistance in adults, irrespective of signs or symptoms.

How accurate are sputum Xpert tests for screening for active pulmonary tuberculosis and rifampicin resistance in adults whether or not they have tuberculosis symptoms?

Cochrane Systematic Review: NEW

WHO consolidated guidelines on tuberculosis Module 2: Screening – Systematic screening for tuberculosis disease

A set of 17 new and updated recommendations for the screening of TB disease have been developed

Dissemination products

WHO: Updated recommendations on HIV prevention, infant diagnosis, antiretroviral initiation and monitoring

These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living with HIV who are being treated for tuberculosis.

Dissemination products

Update (16 Mar 2021) Thoracic imaging tests for the diagnosis of COVID‐19

Original version published on 30 September 2020. This is the second update of this review. The review authors included studies in people with suspected COVID‐19 only, and excluded studies in people with confirmed COVID‐19. The evidence is up to date to 30 September 2020.

Cochrane Systematic Review: UPDATE

Podcast: How accurate are tests (Xpert Ultra and Xpert MTB/RIF) for diagnosing tuberculosis outside the lungs (extrapulmonary tuberculosis) and rifampicin resistance?

First author, Mikashmi Kohli from McGill University in Montreal Canada, tells us about the updating of the review and what they found.

Updated Podcast: Can symptoms and medical examination accurately diagnose COVID-19?

This review, first published in June 2020 has been updated in February 2021. Here the lead author, Thomas Struyf from the Katholieke Universiteit Leuven in Belgium, tells us about the latest findings.

Update (23 Feb 2021) Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19

This review update will assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID‐19 clinics, has COVID‐19.

Cochrane Systematic Review: UPDATE

Update: Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

Why is improving the diagnosis of pulmonary tuberculosis important?

Cochrane Systematic Review: UPDATE

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