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Latest resources

Podcast: How accurate are rapid antigen tests for diagnosing COVID-19?

Listen to this podcast on how accurate are rapid antigen tests for diagnosing COVID-19?

Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

The combination of nirmatrelvir with ritonavir (Paxlovid®) is a new medicine developed to treat infection with the SARS‐CoV‐2 virus and aims to avoid severe COVID‐19 in people without symptoms, or those with mild symptoms. This new review assessed the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid®) plus standard of care compared to standard of care with or without placebo, or any other intervention for treating COVID‐19 and for preventing SARS‐CoV‐2 infection

Cochrane Systematic Review: NEW

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Shortened treatment regimens versus the standard regimen for drug‐sensitive pulmonary tuberculosis

Evaluating the efficacy and safety of shortened treatment regimens versus the standard six‐month treatment regimen for individuals with drug‐sensitive pulmonary tuberculosis.

Cochrane Systematic Review: NEW

Moving towards universal health coverage: Strengthening the evidence ecosystem for the South African health system

Health policy and systems research (HPSR) guides health system reforms and is essential for South Africa (SA)’s progress towards universal coverage of high-quality healthcare.

Peer-reviewed article

Intermittent preventive treatment for malaria in infants

Intermittent preventive treatment could help prevent malaria in infants (IPTi) living in areas of moderate to high malaria transmission in sub‐Saharan Africa.

Cochrane Systematic Review: NEW

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related disease in females and males

Evaluating the efficacy, immunogenicity, and harms of different dose schedules and different types of HPV vaccines in females and males.

Cochrane Systematic Review: NEW

Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations

Most studies evaluating the effect of Xpert MTB/RIF testing for tuberculosis (TB) concluded that it did not reduce overall mortality compared to usual care.

Peer-reviewed article

Lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis of active tuberculosis in people living with HIV Policy update (2019)

The Global TB Programme convened a GDG meeting on 14–16 May 2019, in Geneva, Switzerland, to review the evidence for the use of LF-LAM.

Dissemination products

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV

This review update asks the question, "does new evidence justify the use of LF‐LAM in a broader group of people?”, and is part of the WHO process for updating guidance on the use of LF‐LAM.

Cochrane Systematic Review: UPDATE

Influencing the evidence ecosystem – a reflection

Professor Taryn Young's Inaugural lecture at Stellenbosch University on 11th October 2019

Podcast: Xpert MTB/RIF and Xpert Ultra for diagnosing pulmonary tuberculosis and rifampicin resistance in adults

This podcast is for an earlier version of this review Lead author, David Horne from the University of Washington in Seattle in the USA, sets the scene and tells us what the review found.

Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV‐positive individuals

To determine the diagnostic accuracy of abdominal ultrasound for detecting abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV‐positive individuals.

Cochrane Systematic Review: NEW

Podcast: Effects of starting antiretroviral therapy within one week of diagnosis on people living with HIV

Lead author, Alberto Mateo from the Liverpool School of Tropical Medicine in the UK, tells us about the evidence base and the findings for this important question.

Interventions to improve disposal of child faeces for preventing diarrhoea and soil‐transmitted helminth infection

Assess the effectiveness of interventions to improve the disposal of child faeces for preventing diarrhoea and STH infections.

Cochrane Systematic Review: NEW

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