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Latest resources

New review: The effect of sample site and collection procedure on identification of SARS‐CoV‐2 infection

The review authors compared the sensitivity of different sampling collection sites and methods for the detection of current SARS‐CoV‐2 infection with any molecular or antigen‐based test.

Cochrane Systematic Review: NEW

Evaluation of a strategic academic-government partnership to advance COVID-19 clinical practice guidelines access and uptake in South Africa

The authors of this publication used Cochrane’s KT Framework to map and analyse COVID-19 response activities instituted by a strategic academic-government partnership to supportEIDMduring the COVID-19 pandemic in South Africa.

Peer-reviewed article

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Podcast: How accurate are rapid tests for diagnosing COVID-19?

Several COVID-19 reviews relate to diagnosis. One of these, on the use of rapid point-of-care tests was updated in March 2021. Lead author Jacqueline Dinnes from the University of Birmingham in the UK tells us what they found for antigen tests.

Update (24 Mar 2021): Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection

This is a review update of the original version (published 26 August 2020). The authors now include 64 study reports in 78 study cohorts, evaluating 16 antigen and 5 molecular assays.

Cochrane Systematic Review: UPDATE

Xpert MTB/RIF and Xpert Ultra assays for screening for pulmonary tuberculosis and rifampicin resistance in adults, irrespective of signs or symptoms.

How accurate are sputum Xpert tests for screening for active pulmonary tuberculosis and rifampicin resistance in adults whether or not they have tuberculosis symptoms?

Cochrane Systematic Review: NEW

WHO consolidated guidelines on tuberculosis Module 2: Screening – Systematic screening for tuberculosis disease

A set of 17 new and updated recommendations for the screening of TB disease have been developed

Dissemination products

WHO: Updated recommendations on HIV prevention, infant diagnosis, antiretroviral initiation and monitoring

These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living with HIV who are being treated for tuberculosis.

Dissemination products

Update (16 Mar 2021) Thoracic imaging tests for the diagnosis of COVID‐19

Original version published on 30 September 2020. This is the second update of this review. The review authors included studies in people with suspected COVID‐19 only, and excluded studies in people with confirmed COVID‐19. The evidence is up to date to 30 September 2020.

Cochrane Systematic Review: UPDATE

Podcast: How accurate are tests (Xpert Ultra and Xpert MTB/RIF) for diagnosing tuberculosis outside the lungs (extrapulmonary tuberculosis) and rifampicin resistance?

First author, Mikashmi Kohli from McGill University in Montreal Canada, tells us about the updating of the review and what they found.

Updated Podcast: Can symptoms and medical examination accurately diagnose COVID-19?

This review, first published in June 2020 has been updated in February 2021. Here the lead author, Thomas Struyf from the Katholieke Universiteit Leuven in Belgium, tells us about the latest findings.

Update (23 Feb 2021) Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19

This review update will assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID‐19 clinics, has COVID‐19.

Cochrane Systematic Review: UPDATE

Update: Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

Why is improving the diagnosis of pulmonary tuberculosis important?

Cochrane Systematic Review: UPDATE

Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19

Hydroxychloroquine does not reduce deaths from COVID-19, and probably does not reduce the number of people needing mechanical ventilation, state the authors of a new Cochrane Review.

Cochrane Systematic Review: NEW

A mega-aggregation framework synthesis of the barriers and facilitators to linkage, adherence to ART and retention in care among people living with HIV

This review aims to make sense of existing qualitative evidence syntheses that explore the barriers and facilitators of adherence to antiretroviral treatment.

Peer-reviewed article

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